All Methods

All Methods#

💡 Tip: Click the  + in the first column to expand detailed method descriptions.

MethodYearTask ModelPublishedCode
AMICI 2025
Linear Gene ProgrammesMulti-component Disentanglement
Linear DecoderCross-attentionSpatially-informed
GitHub
ARTEMIS 2025
Trace Cell Populations
VAESchrödinger Bridge
GitHub
AttentionPert 2024
Combinatorial Effect PredictionUnseen Perturbation Prediction
Transformer ModelGNN
GitHub
AUGUR 2020
Perturbation ResponsivenessDifferential Analysis
Random Forrest
GitHub
AVICI 2022
Causal Structure
Amortized pre-trainingVariational Inference
GitHub
Bicycle 2023
Causal Structure
Graph interventionsOrnstein-Uhlenbeck processSteady-State ODE
GitHub
Biolord 2024
Multi-component DisentanglementUnseen Perturbation PredictionCombinatorial Effect PredictionContext Transfer
ProbabilisticZINB likelihoodProtein-Count (totalVI) Likelihood
GitHub
C2S-Scale 2025
Unseen Perturbation PredictionCombinatorial Effect Prediction
Family of LLMs with to 27B parameters
GitHub
CausCell 2024
Multi-component DisentanglementCausal StructureCombinatorial Effect PredictionContext TransferSeen Perturbation Prediction
DiffusionAuxilary Classifiers
GitHub
Celcomen 2025
Unsupervised DisentanglementFeature Relationships
K-hop ConvolutionSpatially-informed
GitHub
CellBox 2021
Context TransferSeen Perturbation PredictionCombinatorial Effect Prediction
ODE
GitHub
CellCap 2024
Multi-component DisentanglementLinear Gene Programmes
VAEAttentionLinear Decoder
GitHub
CellDISECT 2025
Nonlinear Gene ProgrammesContrastive DisentanglementContext Transfer
VAEMixture of Experts
GitHub
CellDrift 2022
Differential Analysis
Generalised Linear ModelNB LikelihoodFunctional PCAFuzzy ClusteringTime-resolvedPerturbation-Covariate Interactions
GitHub
cellFlow 2025
Trace Cell PopulationsContext TransferUnseen Perturbation PredictionCombinatorial Effect Prediction
Conditional Flow MatchingOptimal Transport
GitHub
CellOracle 2023
GRN Inference
Multi-modalPrior Knowledge InformedRegularised (Linear) Regression
GitHub
CellOT 2023
Trace Cell PopulationsPerturbation ResponsivenessContext Transfer
Dual (min-max) Formulation OT
GitHub
CFGen 2024
Trace Cell PopulationsContext Transfer
Optimal TransportMulti-modalConditional Flow Matching
GitHub
ChemCPA 2022
Unseen Perturbation PredictionContext TransferMulti-component Disentanglement
AE framework inspired by CPAChemical representation embeddings
GitHub
CINEMA-OT 2023
Trace Cell PopulationsPerturbation ResponsivenessUnsupervised Disentanglement
Unbalanced OTEntropy-regularized SinkhornICA
GitHub
CIV 2023
Causal Structure
Active LearningStructural Causal ModelDAG-Bayesian linear regression
cLVM 2019
Linear Gene ProgrammesContrastive Disentanglement
Factor ModelsContastive VAE
GitHub
CODEX 2024
Combinatorial Effect PredictionUnseen Perturbation PredictionContext Transfer
DNN
GitHub
CondOT 2022
Trace Cell PopulationsUnseen Perturbation PredictionCombinatorial Effect PredictionContext Transfer
Conditioned Dual (min-max) Formulation OT
GitHub
ContrastiveVI 2023
Nonlinear Gene ProgrammesContrastive Disentanglement
ZINB LikelihoodProtein-Count (totalVI) LikelihoodContrastive VAEMulti-modal
GitHub
ContrastiveVI+ 2024
Perturbation ResponsivenessContrastive DisentanglementNonlinear Gene Programmes
ZINB LikelihoodVAEContrastive
GitHub
CoSpar 2022
Trace Cell Populations
Optimal TransportSparsity
GitHub
CPA 2023
Context TransferCombinatorial Effect PredictionMulti-component Disentanglement
VAEDANN-based Adversary that attempts to eliminate treatment effects/ cellular context from latent representation
GitHub
cPCA 2018
Linear Gene ProgrammesContrastive Disentanglement
Modified PCA
GitHub
CPLVMs 2022
Linear Gene ProgrammesContrastive Disentanglement
NB likelihoodFactor Models
GitHub
CSMF 2019
Linear Gene ProgrammesContrastive Disentanglement
NMF
GitHub
cVAE 2019
Contrastive Disentanglement
Contrastive VAE
GitHub
cycleCDR 2024
Unseen Perturbation Prediction
Autoencoder
GitHub
CytoBridge 2025
Trace Cell PopulationsContext TransferSeen Perturbation Prediction
Neural ODEFlow MatchingOptimal TransportTime-resolvedMean Field Model
GitHub
DAG-GNN 2019
Causal Structure
Continuous optimisation for acyclicityGNN
GitHub
DCD-FG 2022
Causal Structure
Factor ModelDAGsLatent DAGs
GitHub
DCDI 2020
Causal Structure
Graph interventionsDNNNormalizing-Flows
GitHub
DCI 2021
Causal Structure
PC Algorithm
GitHub
Decipher 2024
Unsupervised DisentanglementLinear Gene Programmes
VAELinear Decoder
GitHub
DeepRUOT 2025
Trace Cell PopulationsContext TransferSeen Perturbation Prediction
Neural ODEFlow MatchingOptimal TransportTime-resolvedFisher-regularized Unbalanced Dynamics
GitHub
DIALOGUE 2022
Linear Gene Programmes
Sparse CCAPartial CorrelationsMixed Linear Model
GitHub
Dictys 2023
GRN InferenceCausal Structure
Ornstein–Uhlenbeck processSteady-State ODE
GitHub
discrepancy-VAE 2023
Multi-component DisentanglementSeen Perturbation PredictionCombinatorial Effect PredictionCausal Structure
VAEDisentanglement via Virtual Counterfactuals
GitHub
Dr.VAE 2019
Context TransferSeen Perturbation Prediction
VAE
GitHub
DRVI 2024
Unsupervised DisentanglementNonlinear Gene Programmes
VAENB likelihoodAddative DecodersMulti-modal
GitHub
Expimap 2023
Nonlinear Gene Programmes
VAELinear DecoderNB likelihoodPK Representations
GitHub
EXPORT 2024
Linear Gene Programmes
VAELinear DecoderPK Representations
GitHub
FCR 2024
Multi-component DisentanglementSeen Perturbation Prediction
VAEAdversarialPerturbation-covariate Interactions
GitHub
FLeCS 2025
Context TransferGRN InferenceCausal Structure
ODEOptimal Transport
GitHub
GEARS 2023
Combinatorial Effect PredictionUnseen Perturbation Prediction
GNNs for co-expression and GO relationshipsLabel embeddingsPK Representations
GitHub
GEASS 2023
Nonlinear Gene Programmes
Non-linear Granger CausalityStochastic Gate Layers (Feature Selectors)Time-resolved / Spatially-informed
GEDI 2024
Linear Gene Programmes
ProbabilisticSample-specific DecodersPK Representations (optional)RNA Velocity (optional)
GitHub
GeneCompass 2024
Unseen Perturbation PredictionCombinatorial Effect PredictionGRN InferenceNonlinear Gene Programmes
Foundational Gene expression embeddings (from >50M human cells)Self-supervised masked regression with down-samplingSparse transformer encoderPerformer-style attention decoderPK-informed
GitHub
Geneformer 2023
GRN Inference
Foundational Gene expression embeddings (from ~30M human cells)Self-supervised masked regressionStandard transformer attention
GitHub
graphVCI 2023
Context Transfer
Dual-branch variational bayes causal inference frameworkPK Representations
GitHub
GSFA 2024
Multi-component DisentanglementCausal StructureLinear Gene Programmes
Factor AnalysisProbabilistic
GitHub
GWOT 2025
Trace Cell PopulationsContext Transfer
Optimal TransportMulti-modal
GitHub
Hotspot 2021
Nonlinear Gene ProgrammesFeature Relationships
AutocorrelationPairwise Local Correlations
GitHub
inVAE 2024
Multi-component DisentanglementNonlinear Gene Programmes
VAENB Likelihood
GitHub
IterPert 2024
Unseen Perturbation PredictionCombinatorial Effect Prediction
GEARSActive Learning
GitHub
Kasumi 2025
Feature Relationships
Spatially-informedRandom Forrest (or other regression models)Convolution Operations
GitHub
LEMUR 2025
Seen Perturbation PredictionDifferential Analysis
Multi-condition PCA
GitHub
LINGER 2024
GRN Inference
Multi-modalPrior Knowledge InformedShapley valuesDNN
GitHub
LLM+GP 2024
Unseen Perturbation Prediction
Gaussian Process ModelLanguage embeddings
LPM 2025
Unseen Perturbation PredictionCombinatorial Effect Prediction
DNN Decoder
MEFISTO 2022
Linear Gene ProgrammesUnsupervised Disentanglement
Group Factor ModelMulti-modalSpatially-informedTime-resolved
GitHub
MELD(-VCF) 2021
Perturbation Responsiveness
Manifold LearningVertex-frequency analysisGraph Diffusion
GitHub
Memento 2024
Differential AnalysisLinear Gene ProgrammesFeature Relationships
Hypergeometric testProbabilistic
GitHub
MFM 2024
Trace Cell PopulationsContext TransferSeen Perturbation Prediction
Flow MatchingOptimal TransportTime-resolved
GitHub
MichiGAN 2021
Unsupervised DisentanglementSeen Perturbation PredictionCombinatorial Effect Prediction
VAEconditioned GAN
GitHub
MiloDE 2024
Differential Analysis
Generalised Linear ModelNB Likelihood
GitHub
MioFlow 2022
Trace Cell Populations
Neural ODEGeodasic Autoencoder
GitHub
MISTy 2022
Feature Relationships
Spatially-informedRandom Forrest (or other regression models)
GitHub
Mixscale 2025
Differential AnalysisPerturbation Responsiveness
Gaussian Mixture ModelWeighted multivariate regression
GitHub
Mixscape 2021
Perturbation ResponsivenessLinear Gene Programmes
Gaussian Mixture ModelLDA
GitHub
MMFM 2024
Trace Cell PopulationsContext TransferSeen Perturbation Prediction
Flow MatchingOptimal TransportTime-resolved
GitHub
mmVAE 2022
Contrastive Disentanglement
Contrastive VAE
GitHub
MOFA+ 2020
Linear Gene ProgrammesUnsupervised Disentanglement
Group Factor ModelMulti-modal
GitHub
MOFAcell 2023
Linear Gene Programmes
Group Factor Analysis (MOFA+)
GitHub
moscot 2025
Trace Cell Populations
Unbalanced OTEntropy-regularised SinkhornLow-rank OTSparse Map OT
GitHub
MultiCPA 2022
Combinatorial Effect PredictionMulti-component Disentanglement
AE framework inspired by CPAtotalVI likelihood
GitHub
MultiGroupVI 2022
Nonlinear Gene ProgrammesContrastive Disentanglement
ZINB LikelihoodVAEContrastive
GitHub
MUSIC 2019
Perturbation ResponsivenessLinear Gene Programmes
Topic Model
GitHub
MuVi 2023
Linear Gene ProgrammesUnsupervised Disentanglement
Group Factor ModelPK RepresentationsMulti-modal
GitHub
NicheCompass 2024
Linear Gene Programmes
Graph VAELinear DecoderNB LikelihoodSpatially-informedPK RepresentationsMulti-modal
GitHub
NODAGS-Flow 2023
Causal Structure
Graph interventionsDNNResidual Flow\nSteady-State ODE
GitHub
NOTEARS-MLP 2020
Causal Structure
Continuous optimisation for acyclicityDNN
GitHub
NOTEARS 2018
Causal Structure
Continuous optimisation for acyclicity
GitHub
OmiCLIP 2025
Context Transfer
ViTContrastive LearningMulti-modal
GitHub
ontoVAE 2023
Linear Gene Programmes
VAELinear DecoderPK Representations
GitHub
OT-CFM 2024
Trace Cell Populations
Flow MatchingSchrödinger Bridge
GitHub
PCPCA 2024
Linear Gene ProgrammesContrastive Disentanglement
modified PCA
GitHub
PDGrapher 2025
Combinatorial Effect PredictionUnseen Perturbation PredictionContext Transfer
GNN
GitHub
Perturbation Score 2025
Perturbation ResponsivenessDifferential Analysis
Robust Rank AggregateRidge RegressionRegularised Linear Models
GitHub
pmVAE 2021
Linear Gene Programmes
Multiple VAEsPK Representations
GitHub
PrePR-CT 2024
Context Transfer
Graph attentionRegression
GitHub
Prescient 2021
Trace Cell PopulationsSeen Perturbation PredictionContext Transfer
Diffusion
GitHub
PRNet 2024
Unseen Perturbation Prediction
DNN
GitHub
Prophet 2024
Unseen Perturbation PredictionContext Transfer
TransformerMulti-modalKnowledge Informed
GitHub
RENGE 2023
Context TransferGRN InferenceCausal Structure
Regression model
GitHub
RiTINI 2024
GRN InferenceCausal StructureContext Transfer
Graph interventionsGraph-ODE
GitHub
River 2024
Differential Analysis
Non-linear ClassifierFeature AttributionSpatially-informed
GitHub
SALT&PEPER 2024
Combinatorial Effect Prediction
Additive ModelDNN
SAMS-VAE 2023
Multi-component DisentanglementCausal StructureSeen Perturbation PredictionCombinatorial Effect Prediction
VAENB likelihoodConditional Latent EmbeddingsAddative ShiftSparse Mechanism Shift
GitHub
SBALIGN 2023
Trace Cell Populations
Schrödinger Bridge
GitHub
SC-VAE 2024
Contrastive DisentanglementPerturbation Responsiveness
VAENB likelihood
scCausalVI 2025
Causal StructureUnsupervised DisentanglementSeen Perturbation PredictionContext TransferMulti-component DisentanglementPerturbation ResponsivenessDifferential Analysis
Variational AutoencoderStructural Causal Model
GitHub
SCCVAE 2025
Unseen Perturbation PredictionCausal Structure
VAEVariational InferenceLatent Causal Structure
GitHub
scDiffusion 2024
Context Transfer
DiffusionVAE
GitHub
scDisInFact 2024
Contrastive DisentanglementNonlinear Gene ProgrammesSeen Perturbation PredictionCombinatorial Effect Prediction
VAENB likelihoodAdversarialGaussian Mixture Model
GitHub
scDIST 2024
Perturbation ResponsivenessDifferential Analysis
Generalised Linear Model
GitHub
scDoRI 2025
GRN Inference
Multi-modalPrior Knowledge InformedAutoencoderTopic Modelling
GitHub
scDSA 2023
Nonlinear Gene ProgrammesContrastive Disentanglement
NB likelihoodDomain-Adversarial NNsVAEAddative Shift
scELMo 2024
Seen Perturbation Prediction
Converts gene/cell metadata into text embeddingsIntegrates text and expression embeddingsFine-tunes embeddings via a lightweight neural adaptor
GitHub
SCENIC+ 2022
GRN Inference
Multi-modalPrior Knowledge InformedGradient Boosting
GitHub
SCEPTRE 2021
Differential AnalysisPerturbation Responsiveness
Conditional ResamplingGeneralised Linear ModelNB Likelihood
GitHub
scETM 2021
Linear Gene Programmes
VAEEmbedding Topic ModelLinear DecoderPK Representations
GitHub
scFoundation 2024
Nonlinear Gene ProgrammesUnseen Perturbation PredictionCombinatorial Effect Prediction
Foundational Gene expression embeddings (from >50M human cells)Self-supervised masked regression with down-samplingSparse transformer encoderPerformer-style attention decoder
GitHub
scGEN 2019
Context Transfer
VAE
GitHub
scGenePT 2025
Unseen Perturbation PredictionCombinatorial Effect PredictionGRN InferenceNonlinear Gene Programmes
scGPTChatGPT prompts
scGPT 2024
Unseen Perturbation PredictionCombinatorial Effect PredictionGRN InferenceNonlinear Gene Programmes
Foundational Gene expression embeddings (from >33M human cells)Self-supervised masked expression predictionCustomised non-sequential (flash) attention
GitHub
scINSIGHT 2022
Contrastive DisentanglementLinear Gene Programmes
NMF
GitHub
scITD 2024
Linear Gene Programmes
Tensor Decomposition (Tucker)
GitHub
scMAGeCK 2020
Differential Analysis
Robust Rank AggregateRidge Regression
GitHub
scPCA 2020
Linear Gene ProgrammesContrastive Disentanglement
Modified PCA
GitHub
scPRAM 2024
Context TransferTrace Cell Populations
VAEOTAttention
GitHub
scPreGan 2022
Seen Perturbation Prediction
AEGAN
GitHub
scPrint 2025
GRN InferenceMulti-component DisentanglementNonlinear Gene Programmes
Foundational Gene expression embeddings (from >50M human cells)BERT-like Bidirectional transformers (with flashattention2)Self-supervised masked regressionA classifier decoderZINB likelihood decoderPK Representations
GitHub
scRANK 2024
Linear Gene ProgrammesPerturbation ResponsivenessGRN Inference
PC RegressionTensor Decomposition (PARAFAC)Network Diffusion
GitHub
scVI 2018
Nonlinear Gene Programmes
VAEZINB likelihood
GitHub
SEA 2024
Causal Structure
Amortized pre-trainingTransfomerGraph Attention
GitHub
SENA 2024
Causal StructureMulti-component DisentanglementSeen Perturbation PredictionCombinatorial Effect Prediction
Discrepancy-VAE architectureVAEPK Representations
GitHub
SIMVI 2025
Nonlinear Gene ProgrammesUnsupervised Disentanglement
ZINB LikelihoodVAESpatially-informedMulti-modal
GitHub
SOFA 2024
Multi-component Disentanglement
Group Factor Analysis
GitHub
SpaCeNet 2024
Feature Relationships
Generalised Gaussian Graphical ModelSpatially-informed
GitHub
sparseVAE 2022
Unsupervised Disentanglement
VAE
GitHub
SpatialDIVA 2025
Multi-component Disentanglement
VAESpatially-informedNB LikelihoodMulti-modal
GitHub
Spectra 2023
Linear Gene ProgrammesMulti-component Disentanglement
Poisson LikelihoodFactor AnalysisPK Representations
GitHub
Squidiff 2025
Combinatorial Effect PredictionContext TransferUnseen Perturbation Prediction
Diffusion Model
GitHub
STAMP 2024
Linear Gene ProgrammesUnsupervised Disentanglement
Spatially-informedTime-resolvedGraph encoderFactor Analysis
GitHub
State 2025
Combinatorial Effect PredictionContext Transfer
DNNAttention
GitHub
SubCell 2024
Context TransferNonlinear Gene Programmes
A collection of Vision Transformer ModelsContrastive loss
GitHub
svae-ligr 2024
Seen Perturbation PredictionContext TransferMulti-component DisentanglementCausal Structure
VAENB likelihoodSparse Mechanism ShiftGenerative/Experience Replay
GitHub
sVAE+ 2023
Seen Perturbation PredictionMulti-component DisentanglementCausal StructureNonlinear Gene Programmes
VAENB likelihoodSparse Mechanism Shift
GitHub
Taichi 2024
Perturbation ResponsivenessDifferential Analysis
Graph DiffusionK-meansLogistic RegressionSpatially-informed
GitHub
TarDis 2024
Multi-component DisentanglementContext Transfer
VAENB likelihoodMulti-modal
GitHub
trVAE 2020
Context TransferSeen Perturbation PredictionMulti-component Disentanglement
CVAE
GitHub
VCI 2024
Context TransferSeen Perturbation Prediction
Dual-branch variational bayes causal inference framework
GitHub
VEGA 2023
Linear Gene Programmes
VAELinear DecoderPK Representations
GitHub
Vespucci 2024
Perturbation ResponsivenessDifferential Analysis
Random ForrestSpatially-Informed
GitHub
VirTues 2025
Context Transfer
ViTMaked AutoencoderMulti-modal
GitHub
Waddington-OT 2019
Trace Cell PopulationsLinear Gene Programmes
Unbalanced OTEntropy-regularized Sinkhorn
GitHub