Unsupervised Disentanglement#
💡 Tip: Click the + in the first column to expand detailed method descriptions.
| Method | Year | Task | Model | Published | Code | |
|---|---|---|---|---|---|---|
| Celcomen | 2025 | Unsupervised DisentanglementFeature Relationships |
K-hop ConvolutionSpatially-informed |
✓ | GitHub | |
| CINEMA-OT | 2023 | Trace Cell PopulationsPerturbation ResponsivenessUnsupervised Disentanglement |
Unbalanced OTEntropy-regularized SinkhornICA |
✓ | GitHub | |
| Decipher | 2024 | Unsupervised DisentanglementLinear Gene Programmes |
VAELinear Decoder |
✗ | GitHub | |
| DRVI | 2024 | Unsupervised DisentanglementNonlinear Gene Programmes |
VAENB likelihoodAddative DecodersMulti-modal |
✓ | GitHub | |
| MEFISTO | 2022 | Linear Gene ProgrammesUnsupervised Disentanglement |
Group Factor ModelMulti-modalSpatially-informedTime-resolved |
✓ | GitHub | |
| MichiGAN | 2021 | Unsupervised DisentanglementSeen Perturbation PredictionCombinatorial Effect Prediction |
VAEconditioned GAN |
✓ | GitHub | |
| MOFA+ | 2020 | Linear Gene ProgrammesUnsupervised Disentanglement |
Group Factor ModelMulti-modal |
✓ | GitHub | |
| MuVi | 2023 | Linear Gene ProgrammesUnsupervised Disentanglement |
Group Factor ModelPK RepresentationsMulti-modal |
✓ | GitHub | |
| scCausalVI | 2025 | Causal StructureUnsupervised DisentanglementSeen Perturbation PredictionContext TransferMulti-component DisentanglementPerturbation ResponsivenessDifferential Analysis |
Variational AutoencoderStructural Causal Model |
✓ | GitHub | |
| SIMVI | 2025 | Nonlinear Gene ProgrammesUnsupervised Disentanglement |
ZINB LikelihoodVAESpatially-informedMulti-modal |
✓ | GitHub | |
| sparseVAE | 2022 | Unsupervised Disentanglement |
VAE |
✓ | GitHub | |
| STAMP | 2024 | Linear Gene ProgrammesUnsupervised Disentanglement |
Spatially-informedTime-resolvedGraph encoderFactor Analysis |
✓ | GitHub |